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The cardiac system consists of, and depends on, an array of micro and macro physiological entities and numerous functional characteristics, ranging from molecular reactions and genetic signaling to global ventricular interacting functions. These include diffusion, active ionic transport, membrane channels and receptors, cellular metabolism, intra- and inter-cellular interactions, energy consumption and power generation, electrical excitation, fiber mechanics, fiber orientation and 3D ventricular mechanics, systemic coronary flow circulation, microcirculation and, not least important, pathological factors affecting the various cardiac functions. Understanding this complex multi-parameter, multi-level system, denoted as the Cardionome, or Cardiome, requires in depth study of the interactions between the various physiological and physical parameters and utilizing integrated models and/or sophisticated experimental procedures.
The lecture series presented in August 2004 in the Institute of Fundamental Technological Research of Polish Academy of Sciences in Warsaw aimed to introduce the Cardiome, report experimental and theoretical studies and analyses of this highly complex system from different points of view, and attempt to relate and quantify the effects of some major interacting parameters on the cardiac function.
A salient feature of the seminar series was its integrated presentation of interdisciplinary topics: cell biology concepts and analytic and kinetic modeling were coupled with mechanistic biological and engineering perspectives. The succinct presentations, rich in information and structured in organization, are valuable tools for future research efforts. The lectures distilled the essence of the complex cardiac system and highlighted pertinent approaches for better understanding and improved insight into the molecular mechanisms of cardiac contraction.